I-Insight into Synthesis ye-2-Bromo-1-[4-(Methylsulfonyl) Phenyl]-1-Ethanone

I-Jiangsu Jingye Pharmaceuticaliyaziqhenya ukwethula i-akhawunti enemininingwane yenqubo yokukhiqiza enye yezinhlanganisela zethu eziphambili, i-2-Bromo-1-[4-(Methylsulfonyl) Phenyl]-1-Ethanone, okuphakathi okunemisebenzi eminingi ekuhlanganiseni kwemithi.

Isingeniso:

2-Bromo-1-[4-(Methylsulfonyl) Phenyl]-1-Ethanone, eyaziwa ngokusetshenziswa kwayo ekuhlanganiseni inhlanganisela ye-carbonyl, iyingxenye ebalulekile yokwenziwa kwemithi ehlukahlukene, ama-API, namakhemikhali okwenziwa ngokwezifiso. Ngenombolo ye-CAS ye-50413-24-6 kanye nesisindo samangqamuzana angu-277.14, le nhlanganisela ihlanganiswa ngenqubo yokucophelela eqinisekisa izinga eliphezulu nobumsulwa.

Inqubo ye-synthesis:

Ukuhlanganiswa kwe2-Bromo-1-[4-(Methylsulfonyl) Phenyl]-1-Ethanonekuhilela izinyathelo ezimbalwa ezibalulekile:

1. Ukusebenza Kwendandatho Ye-Phenyl: Inqubo iqala ngokuvula iringi ye-phenyl ukuvumela ukusabela okulandelayo.

2. I-Sulfonylation: Ukwethulwa kweqembu le-methylsulfonyl kwenzeka ngokusabela kwe-sulfonylation, kusetshenziswa i-dimethyl sulfate njenge-ejenti ye-sulfonylating.

3. I-Bromination: Isimo se-alpha se-acetophenone sibe sesingaphansi kwe-bromination, sisebenzisa i-bromine njenge-ejenti ye-halogenating.

4. Ukuhlanzwa: Umkhiqizo ongahluziwe ubhekana nenqubo yokuhlanza eqinile, okuhlanganisa ukwenziwa kabusha kwekristalu kanye ne-chromatography, ukuze kuzuzwe izinga elifiswayo lobumsulwa.

Ukuqinisekisa ikhwalithi:

Umkhiqizo wethu ugqama emakethe ngenxa yekhwalithi yawo ephezulu, esekelwa izinyathelo eziqinile zokulawula ikhwalithi. Iqoqo ngalinye liyahlolwa ukuze kuqinisekiswe ukuthi lihlangabezana nezindinganiso zethu eziphakeme zokuhlanzeka nokungaguquguquki.

Izicelo:

Le nhlanganisela ithola ukusetshenziswa okubanzi embonini yezemithi, isebenza njengendawo ephakathi yokuhlanganiswa kwezithako ezisebenzayo zemithi (APIs). Ukusebenziseka kwayo ngezindlela eziningi kuyenza ifaneleke ukwakheka ngokwezifiso nocwaningo lwamakhemikhali.

Isiphetho:

At I-Jiangsu Jingye Pharmaceutical, sizibophezele ekunikezeni amakhasimende ethu iziphakathi zamakhemikhali zekhwalithi ephezulu njenge-2-Bromo-1-[4-(Methylsulfonyl) Phenyl]-1-Ethanone. Ukuzinikela kwethu ekwenzeni okuhle kubonakala emananini ethu ancintisanayo, ukulethwa okusheshayo, kanye nokuphendula okusheshayo emibuzweni yamakhasimende. Ukuze uthole ulwazi olwengeziwe noma ukufaka i-oda, sicelaXhumana nathi:i-imeyili:guml@depeichem.com/shiyf@depeichem.com. Simagange ukukusiza ngezidingo zakho zamakhemikhali nezemithi.