Ukuthola izinzuzo ezisebenzayo ze- dibenzocycloheptanone: ukubhekisisa ukusetshenziswa kwayo

Emkhakheni wekhemikhali yezokwelapha, izinhlanganisela ezimbalwa ezigqamayo ekusetshenzisweni kwazo okuhlukahlukene nokusebenza kahle njenge- dibenzosuberone. Le nhlanganisela engavamile, eyaziwa nangokuthi i-1011-dihydrodibenzo[a,d]cyclohepten-5-one, idonse ukunaka kwamandla ayo okwelapha emikhakheni eyahlukene yezokwelapha. Ake singene sijule emhlabeni we dibenzosuberone futhi sihlole izinzuzo zawo ekubeni yingxenye ebalulekile yokunakekelwa kwezempilo kwesimanje.

Ngaphambili ocwaningweni lwezokwelapha, i-benzosuberone ikhombisa izakhiwo ezikhuphula kakhulu inani layo. Yaziwa ngekhono layo lokusebenza njenge-prodrug, okusho ukuthi ingaguqulwa ibe ama-pharmacological agents asebenzayo emzimbeni. Lesi sakhiwo esiyingqayizivele sinika amandla imiphumela yokwelapha eyenzelwe wena ngenkathi sinciphisa imiphumela engemihle, ikwenze kube ukukhetha kokuqala ekuthuthukisweni kwezidakamizwa.

Ukusetshenziswa kokwelapha kwe-dibenzocycloconone kubanzi kakhulu futhi kuhlanganisa imikhakha eminingi yezokwelapha. Okubaluleke kakhulu kulokhu indima yayo ekwelapheni ukuphazamiseka kwemizwa. Ucwaningo lukhombisa ukuthi i- dibenzosuberone ingasiza ekudambiseni izimpawu ezihambisana nezimo ezifana nesifo sika-Parkinson, futhi ingasiza ekulawuleni i-dopamine. Ukwengeza, izakhiwo zayo ezingaba yi-anticonvulsant ziye zahlolwa, okusikisela ukusetshenziswa okungenzeka ekwelapheni isithuthwane.

Ngaphezu kwalokho, imiphumela elwa nokuvuvukala ye- dibenzosuberone ifundwe kabanzi, ivula amathuba okusetshenziswa kwayo ekwelapheni izifo ezivuthayo. Kusukela ku-arthritis kuya ezifweni ze-autoimmune, ikhono lale nhlanganisela lokushintsha izimpendulo zokuzivikela komzimba kungaholela ekuthuthukisweni okukhulu kwezokwelapha.

Ngaphezu kwalokhu, i-dibenzosuberone nayo inokusetshenziswa ku-endocrinology. Ikhono layo lokusebenzelana nesistimu yamahomoni omzimba liphakamisa ukuthi lidlala indima ekulawuleni izinqubo ezifana nemetabolism kanye ne-homeostasis yamandla. Lolu hlu olubanzi lwemisebenzi lubonisa ukuguquguquka nokubaluleka kwe-benzosuberone kukhemikhali yezokwelapha yesimanje.

Izinzuzo ze- dibenzocycloconone zidlulela ngale kwemiphumela yayo yokwelapha. Ukwakheka kwayo kwamakhemikhali kushintshwa kalula, okuvumela abacwaningi ukuba bathuthukise okuphuma kokunye ngokusebenza okuthuthukisiwe noma imiphumela eqondiwe. Lokhu kuvumelana nezimo ekwakhiweni nasekusebenziseni kuyenza ithuluzi elibalulekile lokutholwa nokuthuthukiswa kwezidakamizwa.

Kulabo abafuna i-dibenzocycloheptone yekhwalithi ephezulu, i-Jingye Pharmaceutical inikeza izixazululo ezinokwethenjelwa. Iwebhusayithi yabo kuhttps://www.jingyepharma.com/dibenzosuberone-1011-dihydrodibenzoadcyclohepten-5-one-product/inikeza ulwazi olunzulu mayelana nale nhlanganisela ehlukahlukene. I-Jingye Pharmaceuticals izibophezele ekusebenzeni kahle futhi inomlando wokukhiqiza imithi yekhwalithi ephezulu, iqinisekisa ukuthi unokufinyelela okulula nokuthembekile ku- dibenzocycloheptanone.

Kafushane, i- dibenzosuberone ikhombisa intuthuko entsha kwisayensi yezemithi. Uhlu olubanzi lwezinhlelo zokusebenza zalo, kusukela ku-neurology kuya ku-endocrinology, kanye namandla ayo okwenziwa ngokwezifiso kuyenze yaba insika yezindlela zokwelapha zesimanje. Njengoba siqhubeka nokuhlola ukujula kwale nhlanganisela ephawulekayo, izinzuzo ze-dibenzosuberone ngokungangabazeki zizololonga ikusasa eliqhakazile ekunakekelweni kwezempilo.

VakashelaJingyeEzemithi namuhla ukuze ufunde kabanzi mayelana nenqubekelaphambili eyenziwe ku dibenzosuberone futhi ufunde ukuthi le nhlanganisela ingakuguqula kanjani ukuqonda kwakho ukuqanjwa kwemithi.