Ku-pharmacology, i-intermediate iyinhlanganisela ehlanganiswe kusuka kumakhemikhali alula, avame ukusetshenziswa ekuhlanganiseni okulandelayo kwemikhiqizo eyinkimbinkimbi, njengezithako ezisebenzayo zemithi (APIs).
Abaxhumanisi babalulekile ekuthuthukisweni kwezidakamizwa nasenqubweni yokukhiqiza ngoba benza lula ukusabela kwamakhemikhali, behlisa izindleko, noma bakhuphule isivuno somuthi. Izilamuli zingase zingabi nawo umthelela wokwelapha noma zibe nobuthi ngakho-ke azifaneleki ukusetshenziswa abantu.
Ama-Intermediate akhiwa ngesikhathi sokuhlanganiswa kwezinto zokusetshenziswa futhi yizinto ezinemiphumela yokwelapha emithini. Ama-API ayizingxenye ezibalulekile zemithi futhi anquma ikhwalithi, ukuphepha nokusebenza ngempumelelo kwemithi. Ama-API ngokuvamile ahlanganiswa kusuka ezintweni ezingavuthiwe noma emithonjeni yemvelo futhi ahlolwe ngokuqinile futhi avunyelwe ngaphambi kokuba asetshenziselwe ukusetshenziswa abantu.
Umehluko omkhulu phakathi kwama-intermediates nama-APIs ukuthi okuphakathi kuyizinto ezandulelayo ezifaka isandla ekukhiqizweni kwama-API, kuyilapho ama-API ayizinto ezisebenzayo ezifaka isandla ngokuqondile emiphumeleni yokwelapha yomuthi. Izakhiwo nemisebenzi yabamaphakathi ilula futhi ayichazwanga kangako, kuyilapho izinto zezidakamizwa zinezakhiwo nemisebenzi yamakhemikhali eyinkimbinkimbi futhi ethize. Abaphakathi banezidingo zokulawula ezimbalwa kanye nokuqinisekiswa kwekhwalithi, kuyilapho ama-API engaphansi kwamazinga okulawula aqinile kanye nokulawulwa kwekhwalithi.
Ama-Intermediate asetshenziswa kakhulu emikhakheni nasezimbonini ezahlukahlukene njengamakhemikhali amahle, i-biotechnology, namakhemikhali ezolimo. Abaphakathi nabo bahlala bethuthuka futhi bakhula ngokuvela kwezinhlobo ezintsha nezindlela ezintsha zabaphakathi, njengama-chiral intermediates, ama-peptide intermediates, njll.
Abaphakathi bawumgogodla wesayensi yezokwelapha yesimanje njengoba benika amandla ukuhlanganiswa nokukhiqizwa kwama-API nemithi. Abaphakathi bawukhiye wokwenza lula, ukumiswa kanye nokusungula izinto ezintsha kwezemithi, ukuhlinzeka ngekhwalithi engcono yezidakamizwa nokusebenza.
Isikhathi sokuthumela: Feb-28-2024